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Editor's Correspondence
October 28, 2002

Ulcer Prevention in Long-term Users of Nonsteroidal Anti-inflammatory Drugs

Author Affiliations

Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

Arch Intern Med. 2002;162(19):2248-2249. doi:

The recent report by Graham et al1 provides much needed insights into the comparative benefits of 2 gastroprotective therapies: misoprostol and the proton pump inhibitor lansoprazole. Clinicians are now especially eager for evidence-based guidance in the treatment of patients who have a history of endoscopically documented gastric ulceration without Helicobacter pylori infection and who require long-term therapy with a nonsteroidal anti-inflammatory drug (NSAID). However, the use of misoprostol (200 µg 4 times a day [800 µg/d], the maximum recommended dose) does not reflect the current realities of clinical practice.