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Editor's Correspondence
January 27, 2003

Alcohol and Acetaminophen Hepatotoxicity

Arch Intern Med. 2003;163(2):244-245. doi:10.1001/archinte.163.2.244-a

We were pleased to find that our article stimulated discussion on the important topic of acetaminophen use in the alcoholic patient.1 Our study investigated the effects of multiple maximal therapeutic dosing of acetaminophen in alcoholic patients in a controlled and randomized manner. The study was powered to detect very small differences in aspartate aminotransferase and alanine aminotransferase levels: no statistical difference was found between the acetaminophen and placebo groups at any time point.