Literature Reports of Angiotensin Receptor Antagonist–Induced Angioedema in Patients With a History of Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema

It was with grave concern that I read a recent case report by Drs Gavras and Gavras in the January 27, 2003, issue of the ARCHIVES.¹ Their report described no incidents of angioedema following the use of angiotensin receptor antagonists (ARBs) in 10 patients who had previously incurred angioedema secondary to the use of angiotensin-converting enzyme (ACE) inhibitors.¹ Their case report omitted numerous findings from the literature, and as a result the authors' conclusion is dangerously misleading.