An association of aortic stenosis and gastrointestinal bleeding was first reported in 1958.1 Heyde wrote a short letter to the editor, stating that over the past 10 years he had seen at least 10 patients with calcific aortic stenosis who had massive gastrointestinal bleeding "for which we could discover no cause." His patients ranged in age from 60 to 80 years. Most of them had classic signs of aortic stenosis with harsh systolic murmurs transmitted widely to the neck or back and some had palpable systolic thrills. Heyde requested that his letter be published in the hope that it may "stimulate some replies or statistical studies." In response, Schwartz2 stated that he had "noted this association once or twice a year since 1942." Most of his patients were women older than 70, many of whom had recurrent bleeding.
Shindler DM. Aortic Stenosis and Gastrointestinal Bleeding. Arch Intern Med. 2004;164(1):103–104. doi:10.1001/archinte.164.1.103
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