The recent article reporting that being overweight is a risk factor for Alzheimer disease (AD) for women1 is consistent with the growing body of literature on the link between diet and AD.2-7 The primary dietary risk factors are total caloric intake and saturated fat intake,2,4,5,7 while cereals and fish are important risk reduction factors.2,5,6 Cholesterol is also a risk factor.8 It has also been suggested that caloric restriction would reduce the risk of AD.3 In addition, the presence of the APOE ϵ4 allele, the "thrifty gene," greatly increases the risk of AD for a high-risk diet.5
Grant WB. Obesity and Alzheimer Disease: Roles of Diet and Genetics. Arch Intern Med. 2004;164(1):109–110. doi:10.1001/archinte.164.1.109-b
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: