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Editor's Correspondence
February 23, 2004

Adverse Childhood Experiences, Obesity, and Liver Disease

Arch Intern Med. 2004;164(4):460-461. doi:10.1001/archinte.164.4.460-b

In their article "Adverse Childhood Experiences and Self-reported Liver Disease," Dong and colleagues1 report an association between adverse childhood experiences (ACEs) and the risk of self-reported liver diseases including "yellow jaundice, hepatitis, or any liver trouble." Previous work from this cohort indicated an association between ACEs and severe obesity.2 Obesity-related liver diseases such as nonalcoholic steatohepatitis and nonalcoholic fatty liver disease are among the most common liver disorders seen in the primary care population and a significant cause of cryptogenic cirrhosis.3 Can the authors comment as to whether their data suggest that obesity is an intervening variable between ACEs and liver problems experienced later in life?