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Editor's Correspondence
December 13, 2004

The Prognostic Impact of Oral Anticoagulant Treatment in Patients With Intracerebral Hemorrhage—Reply

Arch Intern Med. 2004;164(22):2500-2509. doi:10.1001/archinte.164.22.2505-b

In reply

We agree that hematoma volume and level of consciousness on admission are important predictors of in-hospital mortality from ICH. Indeed, as we discussed, a plausible mechanism for the effect of warfarin sodium on ICH mortality is through the generation of larger hematoma volumes.1 We have investigated this question in a follow-up study and found that while patients receiving warfarin do not have larger hemorrhage volumes on presentation, they do have an increased risk of in-hospital expansion of these volumes.2 Notably, the effect of warfarin on mortality was independent of level of consciousness on admission.

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