In reply
We agree that hematoma volume and level of consciousness on admission are important predictors of in-hospital mortality from ICH. Indeed, as we discussed, a plausible mechanism for the effect of warfarin sodium on ICH mortality is through the generation of larger hematoma volumes.1 We have investigated this question in a follow-up study and found that while patients receiving warfarin do not have larger hemorrhage volumes on presentation, they do have an increased risk of in-hospital expansion of these volumes.2 Notably, the effect of warfarin on mortality was independent of level of consciousness on admission.