The investigation by Leendertse et al1 confirms earlier findings that many hospital admissions related to medications (HARMs) are potentially preventable and that a substantial portion of them involve a handful of long-existing drug classes with pharmacologically predictable effects. The important implication is that clinical risk management should focus not only on new risks of new drugs but also on certain old risks of old drugs. This prompted the setup of an expert “HARM-Wrestling” Group, which has recently presented specific advice concerning 7 categories of adverse effects (ie, hemorrhage, electrolyte disturbances, fractures, disturbances of diabetic control, renal insufficiency and heart failure, constipation, and bradycardia).2
De Smet PAGM. Editor's Correspondence: COMMENTS AND OPINIONS. Arch Intern Med. 2009;169(8):809–813. doi:10.1001/archinternmed.2009.81
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