Over the past 12 years, we have made substantial progress in screening US adults aged 50 to 75 years for colorectal cancer (CRC). In 1999, 44% of US adults were up to date with some form of CRC screening1; in 2002, the proportion had increased to 52%, and it was 63% in 2008.2 Mortality rates for CRC have also decreased substantially over this same period.3 However, despite this increase in screening and reduction in mortality, over one-third of age-eligible US adults were not up-to-date in 2008, and there were substantial disparities based on income, education, and health insurance coverage.2