In 1988, recognizing that there were not enough specialists to care for the burgeoning number of persons with AIDS, Northfelt et al1 wrote an influential editorial titled “The Acquired Immunodeficiency Syndrome Is a Primary Care Disease.” The authors exhorted all physicians to become knowledgeable about how to care for persons with AIDS. At that time, only one antiretroviral agent was available (zidovudine [AZT]) and human immunodeficiency virus (HIV) viral load testing, and HIV-resistance assays had not yet been invented.