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Comment & Response
May 2015

Further Insight Into the Cardiovascular Risk Calculator: Time to Rethink the Strategy?

Author Affiliations
  • 1Department of Primary Care & Public Health, Imperial College London, London, England
JAMA Intern Med. 2015;175(5):862. doi:10.1001/jamainternmed.2015.69

To the Editor The Original Investigation by Cook et al1 and the accompanying Invited Commentary2 in JAMA Internal Medicine outline problems with the process of developing the American College of Cardiology (ACC) and American Heart Association (AHA) Prevention Guidelines and with the associated cardiovascular disease (CVD) risk calculator. Overprediction of CVD risk by the ACC/AHA risk calculator has been demonstrated in the 3 validation cohorts used by guideline developers and in more contemporary data from the derivation cohorts.3 Now, using data from the Women’s Health Study, Cook et al1 have found that statin use, revascularization procedures, and underascertainment of events do not explain the discrepancies.