In Reply We thank Dr Marois and colleagues for their observations on parallels between hyperbaric oxygen (HBO) use in children with cerebral palsy and our findings in soldiers with persistent postconcussive symptoms (PCS). We recognize that the sham arm consisting of pressurized (1.2 atmospheres absolute [ATA]) room air was not inert and may cause physiologic effects from slight increases in oxygen, nitrogen, and direct pressure, as well as a variety of participation effects. The study was not designed to tease apart these effects but rather show a benefit of HBO beyond these effects, which it failed to do.
Miller RS, Weaver LK, Brenner LA. Hyperbaric Oxygen Treatment for Persistent Postconcussion Symptoms—Reply. JAMA Intern Med. 2015;175(7):1240–1241. doi:https://doi.org/10.1001/jamainternmed.2015.1048
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