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Comment & Response
July 2015

Hyperbaric Oxygen Treatment for Persistent Postconcussion Symptoms—Reply

Author Affiliations
  • 1Uniformed Services University of the Health Sciences, Bethesda, Maryland
  • 2LDS Hospital, Salt Lake City, Utah
  • 3University of Utah School of Medicine, Salt Lake City
  • 4Veterans Integrated Service Network 19, Mental Illness Research Education and Clinical Center, Denver, Colorado
  • 5University of Colorado Anschutz Medical Campus, Aurora
JAMA Intern Med. 2015;175(7):1240-1241. doi:10.1001/jamainternmed.2015.1048

In Reply We thank Dr Marois and colleagues for their observations on parallels between hyperbaric oxygen (HBO) use in children with cerebral palsy and our findings in soldiers with persistent postconcussive symptoms (PCS). We recognize that the sham arm consisting of pressurized (1.2 atmospheres absolute [ATA]) room air was not inert and may cause physiologic effects from slight increases in oxygen, nitrogen, and direct pressure, as well as a variety of participation effects. The study was not designed to tease apart these effects but rather show a benefit of HBO beyond these effects, which it failed to do.

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