[Skip to Content]
[Skip to Content Landing]
Regular Departments
February 1982

Hypophosphatemia in Burkitt's Lymphoma

Author Affiliations

Bethesda, Md

Arch Intern Med. 1982;142(2):418. doi:10.1001/archinte.1982.00340150218046

To the Editor.  —In an article in the May Archives (1981;141:805-806), Matzner and co-workers reported the occurrence of hypophosphatemia in a patient with diffuse histiocytic lymphoma in leukemic phase. We have seen a similar complication that occurred in a patient with Burkitt's lymphoma in relapse.

Report of a Case.  —A 16-year-old girl with Burkitt's lymphoma in relapse was referred to us for treatment. She had been initially seen seven months before with a rapid increase in abdominal girth. At laparotomy, a widespread intra-abdominal and retroperitoneal tumor was found. Pathologic findings were consistent with undifferentiated lymphoma of Burkitt's type. The patient was treated with cyclophosphamide (40 mg/kg) given intravenously at monthly intervals. After five months of treatment, she experienced a pericardial, bone marrow, and CNS relapse. Despite additional chemotherapy, she continued to have circulating blast cells and was referred to the National Cancer Institute, Bethesda, Md, for further treatment.Laboratory values