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Comment & Response
March 2016

Discontinuation of Antihypertensive Treatment in Elderly Patients and Cognitive Function

Author Affiliations
  • 1Second Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece
  • 2Department of Medicine, George Washington University, Washington, DC

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Intern Med. 2016;176(3):409. doi:10.1001/jamainternmed.2015.8342

To the Editor The DANTE study1 provided data of high clinical significance considering that it is the very first study evaluating the effect of antihypertensive treatment discontinuation on cognitive function in elderly patients. As mentioned by Moonen et al, the termination of the treatment had no beneficial results on the cognitive, psychological, and general function, even in subgroup analysis based on several factors. We would be obliged to the authors if they performed an additional analysis according to baseline pulse pressure levels and estimated glomerular filtration rate.