Neuraminidase Inhibitors and Influenza Infection

To the Editor As authors of articles cited by Louis and Lampiris,¹ we have a different view of the evidence that should inform recommendations about treating influenza with neuraminidase inhibitors.

Louis and Lampiris¹ champion conclusions from observational studies. They judged the evidence from randomized clinical trials as inadequate because such trials have not been carried out in high-risk populations, which they defined as including children and the elderly. However, we analyzed 13 such placebo-controlled randomized clinical trials in our Cochrane review.²