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Comment & Response
June 2016

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Author Affiliations
  • 1Department of Microbiology and Immunology, Division of Nephrology, University Hospitals Leuven, B-3000 Leuven, Belgium
JAMA Intern Med. 2016;176(6):867-868. doi:10.1001/jamainternmed.2016.1854

To the Editor We read with interest the article by Lazarus et al,1 demonstrating an association between the use of proton pomp inhibitors (PPIs) and elevated risk of incident chronic kidney disease (CKD).1 We hypothesize that, besides recurrent acute kidney injury and hypomagnesemia, altered gut microbial composition and metabolism may be in the causal pathway between PPIs and CKD.

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