To the Editor We read with interest the article by Fenton et al1 published in a recent issue of JAMA Internal Medicine that reported overtreatment of osteoporosis through a retrospective cohort study that included 6150 women aged 40 to 85 years. The authors defined the treatment criteria of osteoporosis should be the T score less than −2.5 at main site. According to their standard, two-thirds of new osteoporosis drug prescriptions could be potentially inappropriate. However, we have some concerns about this study.