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Original Investigation
September 2016

Primary Stroke Center Hospitalization for Elderly Patients With Stroke: Implications for Case Fatality and Travel Times

Author Affiliations
  • 1Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • 2The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire
  • 3Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
  • 4Department of Economics, Dartmouth College, Hanover, New Hampshire
JAMA Intern Med. 2016;176(9):1361-1368. doi:10.1001/jamainternmed.2016.3919

Importance  Physicians often must decide whether to treat patients with acute stroke locally or refer them to a more distant Primary Stroke Center (PSC). There is little evidence on how much the increased risk of prolonged travel time offsets benefits of a specialized PSC care.

Objectives  To examine the association of case fatality with receiving care in PSCs vs other hospitals for patients with stroke and to identify whether prolonged travel time offsets the effect of PSCs.

Design, Setting, and Participants  Retrospective cohort study of Medicare beneficiaries with stroke admitted to a hospital between January 1, 2010, and December 31, 2013. Drive times were calculated based on zip code centroids and street-level road network data. We used an instrumental variable analysis based on the differential travel time to PSCs to control for unmeasured confounding. The setting was a 100% sample of Medicare fee-for-service claims.

Exposures  Admission to a PSC.

Main Outcomes and Measures  Seven-day and 30-day postadmission case-fatality rates.

Results  Among 865 184 elderly patients with stroke (mean age, 78.9 years; 55.5% female), 53.9% were treated in PSCs. We found that admission to PSCs was associated with 1.8% (95% CI, −2.1% to −1.4%) lower 7-day and 1.8% (95% CI, −2.3% to −1.4%) lower 30-day case fatality. Fifty-six patients with stroke needed to be treated in PSCs to save one life at 30 days. Receiving treatment in PSCs was associated with a 30-day survival benefit for patients traveling less than 90 minutes, but traveling at least 90 minutes offset any benefit of PSC care.

Conclusions and Relevance  Hospitalization of patients with stroke in PSCs was associated with decreased 7-day and 30-day case fatality compared with noncertified hospitals. Traveling at least 90 minutes to receive care offset the 30-day survival benefit of PSC admission.