To the Editor We read with interest the Original Investigation by Martin et al1 in a recent issue of JAMA Internal Medicine suggesting that calorie restriction leads to significant benefits on mood, quality of life, sexual function, and sleep quality. The findings of this well-designed study suggest that intake of excess calories is not only a burden to our physical homeostasis but also on our psychological well-being. One previous study2 indicated that, in addition to eating quickly, eating until full was associated with being overweight. Another recent study3 indicated that breaking up prolonged sitting with standing or walking attenuated postprandial metabolic response in postmenopausal women. Furthermore, late-night dinner and bedtime snacking are associated with several health problems including gastroesophageal reflux disease and chronic kidney disease.4,5 We suggest that in the study by Martin et al1 calorie restriction might have theoretically led to several healthy behaviors, including shorter sitting periods for eating, slower eating speed, lower rates of eating until full, and lower rates of night snacking. We wonder if the authors did specific analyses in their study, which has a very detailed and comprehensive protocol.