To the Editor In a recent issue of JAMA Internal Medicine, Harnett et al1 reported 2 interesting cases of isolated right ventricular myocardial infarction (RVMI) with massive anterior ST segment elevation (STE) on presentation electrocardiogram (ECG), mimicking the findings of anterior acute myocardial infarction (AMI). The authors emphasized that anterior STE with no reciprocal changes strongly suggested isolated RVMI. We agree with these points and would like to additionally comment on these cases on the basis of previous studies assessing ECG findings in anterior AMI.2,3