To the Editor In their study of the influence of diet on mortality in a recent issue of JAMA Internal Medicine Wang et al1 argue for a higher intake of ω-6 polyunsaturated fatty acids (PUFA) and a lower intake of saturated fatty acids (SFA), contradicting the better evidence having shown that such a diet is of no benefit. They weigh their own analysis of 2 observational studies including about 126 000 individuals greater than the meta-analysis by Chowdhury et al2 of 46 observational studies and 27 trials including 5 times more participants that found no evidence for their proposition. Wang et al have also ignored a meta-analysis by Siri-Tarino et al3 of 21 cohort studies including almost 350 000 participants that found no association between intake of SFA and mortality.
Ravnskov U, Okuyama H, Harcombe Z. Association of Specific Dietary Fats With Mortality. JAMA Intern Med. 2016;176(12):1878. doi:10.1001/jamainternmed.2016.7125
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