To the Editor In their study of the influence of diet on mortality in a recent issue of JAMA Internal Medicine Wang et al1 argue for a higher intake of ω-6 polyunsaturated fatty acids (PUFA) and a lower intake of saturated fatty acids (SFA), contradicting the better evidence having shown that such a diet is of no benefit. They weigh their own analysis of 2 observational studies including about 126 000 individuals greater than the meta-analysis by Chowdhury et al2 of 46 observational studies and 27 trials including 5 times more participants that found no evidence for their proposition. Wang et al have also ignored a meta-analysis by Siri-Tarino et al3 of 21 cohort studies including almost 350 000 participants that found no association between intake of SFA and mortality.