In Reply We very much welcome the thoughtful comments of van Oers and colleagues on the SISPCT trial.1 We agree that the choice of algorithm to guide antimicrobial therapy and the management of sepsis patients by the course of procalcitonin (PCT) may have an impact on the outcome of such studies. The PCT algorithm in our study differed somewhat from previously published algorithms for other trials including their SAPS trial2 but also encouraged de-escalation of antimicrobial therapy accordingly.
Reinhart K, Bloos F. Procalcitonin-Guided Antimicrobial Therapy—All About the Algorithm—Reply. JAMA Intern Med. 2017;177(1):142–143. doi:10.1001/jamainternmed.2016.7820
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