Migraine is a common and often disabling neurologic disorder. The 1-year prevalence of migraine in the United States is 18% of women and 6% of men.1 While migraine preventive medications exist, they are not necessarily effective for all patients and can cause serious adverse effects. Many patients are interested in nonpharmacologic treatment options for migraine. In this issue of JAMA Internal Medicine, Zhao et al2 report their findings in a randomized clinical trial (RCT) of acupuncture for migraine prevention. Previous studies of acupuncture for migraine prevention have had somewhat conflicting results, with an RCT published in JAMA showing no difference between true acupuncture and sham acupuncture.3