Nonalcoholic steatohepatitis (NASH) and its clinical sequelae have become an increasingly prevalent and important cause of hepatic morbidity and mortality.1 Despite almost 2 decades of intense study, we are still not certain how best to treat NASH. In this issue of JAMA Internal Medicine, Musso and colleagues present a meta-analysis that suggests that thizaolidinedione use is associatyed with improvement in advanced fibrosis in NASH, even in patients without diabetes.2 Other medications in the thiazolidinedione class did not demonstrate a significant effect in treatment of nonalcoholic steatohepatitis, therefore this commentary focuses on pioglitazone. Although this article makes a significant contribution to our understanding of the potential role that this thiazolidinedione may have in the management of NASH, there remain substantive questions that need to be addressed before pioglitazone hydrochloride can be recommended as a treatment for patients with NASH.
Yee HF. The Role of Pioglitazone in the Management of Nonalcoholic Steatohepatitis: Are We There Yet? JAMA Intern Med. 2017;177(5):640–641. doi:https://doi.org/10.1001/jamainternmed.2016.9669
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: