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Comment & Response
April 2017

Blood Donor Characteristics on Transfusion Outcomes—Should Obesity Be Assessed in Future Clinical Trials?

Author Affiliations
  • 1Biochemistry Department, Faculty of Medicine, University of Porto, Porto, Portugal
JAMA Intern Med. 2017;177(4):599. doi:10.1001/jamainternmed.2017.0236

To the Editor The work of Chassé and colleagues1 in a recent issue of JAMA Internal Medicine reported that blood donor (BD) characteristics may affect red blood cell (RBC) transfusion outcomes and describes a higher risk of death for recipients of RBC transfusions from young donors and female donors independently of recipient age, sex, and comorbidities. The authors discuss these results, mentioning the healthy donor phenomenon and the blood composition in female sex, not ruling out unknown biological and/or environmental factors.

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