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In Reply The focus of our Invited Commentary1 was on antibiotic stewardship and we did not go into either the details of the AZALEA trial2 nor its generalizability. The single sentence summary of the AZALEA trial2 in our article1 potentially oversimplifies the findings of the study by Johnston and colleagues. However, we respectfully disagree with Johnston and colleagues that our interpretation of their trial2 was inaccurate. Our summary of the AZALEA trial2 was consistent with the brief summary provided by JAMA Internal Medicine that stated, “This randomized clinical trial found no statistically or clinically significant benefit in symptoms, lung function, or speed of recovery.” Brusselle and Van Braeckel stated, “...addition of azithromycin to standard medical care for acute asthma exacerbations did not result in a statistically or clinically significant benefit.”3(p1637)
Mehrotra A, Linder JA. Incorrect Conclusions Concerning Antibiotics and Asthma Exacerbation—Reply. JAMA Intern Med. 2017;177(4):598–599. doi:10.1001/jamainternmed.2017.0113
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