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Comment & Response
May 2017

Dabigatran Compared With Rivaroxaban vs Warfarin

Author Affiliations
  • 1Pharmacy and Therapeutics Office, Group Corporate Development, National Healthcare Group, Singapore, Singapore
  • 2Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore
JAMA Intern Med. 2017;177(5):742. doi:10.1001/jamainternmed.2017.0564

To the Editor We read with interest the Original Investigation by Graham et al1 in a recent issue of JAMA Internal Medicine comparing treatment-related benefits and risks among elderly Medicare beneficiaries who were treated with dabigatran or rivaroxaban for nonvalvular atrial fibrillation (AF).1 Disconcertingly, the study found substantially higher risks of intracranial hemorrhage and major extracranial bleeding with use of rivaroxaban than dabigatran, with significantly increased mortality in patients 75 years or older.

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