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Comment & Response
July 2017

Neuroleptics for Delirium: More Research Is Needed

Author Affiliations
  • 1Maastricht University Medical Center+, Department of Psychiatry and Psychology, Division of Child and Adolescent Psychiatry and Psychology, Maastricht, Limburg 6202 AZ, Netherlands
  • 2European Graduate School For Neuroscience (EURON)
  • 3South Limbourg Mental Health Research & Teaching Network
  • 4Mutsaersstichting, Venlo
JAMA Intern Med. 2017;177(7):1053. doi:10.1001/jamainternmed.2017.1786

To the Editor With interest and concern we read the Original Investigation in a recent issue of JAMA Internal Medicine by Agar and colleagues1 titled “Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care: A Randomized Clinical Trial.” Agar and colleagues1 basically demonstrate that nonpharmacological delirium treatment is better than treatment with antipsychotics, and although we appreciate the trial outline and careful execution, we have 3 major concerns.

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