In Reply We thank Dr Braillon for his comments. First, we agree that innumeracy and naiveté about clinical epidemiology concepts are some of the underlying contributions to the misperceptions that we report in our systematic review.1 Clinician illiteracy in health statistics has been articulated previously.2,3 However, we disagree that the benefits of interventions are certain while the harms are only a potential risk. Few interventions have certain benefits: there is both the chance of benefit and the chance of harm from most interventions.
Hoffmann TC, Del Mar C. Discrepant Expectations About Benefits and Harms—Reply. JAMA Intern Med. 2017;177(8):1226–1227. doi:10.1001/jamainternmed.2017.2389
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