In Reply Fixed-dose combination products, therapies that contain 2 or more active ingredients incorporated into a single dosage presentation, may play an important role in optimizing patient adherence to dosing regimens and improving patient outcomes. In response to Sherman, however, we question whether the value provided by Duexis (Horizon Pharma) has been uncoupled from its price. In August 2016, the monthly wholesale price of Duexis was $2061; on April 18, 2017, it was $2259.1 The April 2017 price represents a further 9.6% increase beyond the 1131% aggregate increase from 2012 to 2016 that we reported in our Viewpoint.2
Hakim A, Ross JS. Facts Concerning Duexis Prescribing Habits Related to Combination Therapies—Reply. JAMA Intern Med. 2017;177(8):1228. doi:10.1001/jamainternmed.2017.2460
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