• Eye drops are a common form of medication that has been reported to cause a wide range of substantial systemic effects, as reviewed herein. A greater awareness of potential eye drop–related complications is important since these complications are frequently not taken into consideration in a patient's drug history and neglected in a differential diagnosis of adverse reactions.
Alan G. Adler, Guy E. McElwain, Geno J. Merli, John H. Martin. Systemic Effects of Eye Drops. Arch Intern Med. 1982;142(13):2293–2294. doi:10.1001/archinte.142.13.2293