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Comment & Response
September 2017

Redefining Unexplained Anemia in Elderly

Author Affiliations
  • 1Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
JAMA Intern Med. 2017;177(9):1394-1395. doi:10.1001/jamainternmed.2017.2958

To the Editor The Original Investigation by Roy et al1 recently published in JAMA Internal Medicine showed in a well-executed double-blind placebo-controlled trial the efficacy of testosterone supplementation in correcting anemia among older men with low testosterone concentrations. The authors concluded that testosterone supplementation is a feasible approach to increase hemoglobin levels of both unexplained anemia as well as anemia from known causes. The authors first defined known causes of anemia by choosing specific cut-off values and subsequently categorized the remaining group of patients as having an unexplained anemia. However, regarding 2 known causes of anemia, we question whether the authors did not underestimate its prevalence.

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