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Comment & Response
September 2017

Redefining Unexplained Anemia in Elderly—Reply

Author Affiliations
  • 1Center for the Study of Aging & Human Development, Duke University Medical Center, Durham, North Carolina
  • 2Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 3Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA Intern Med. 2017;177(9):1395. doi:10.1001/jamainternmed.2017.2970

In Reply We appreciate the comments of Eisenga et al regarding our classification of the anemias in our Original Investigation.1 They question our choices of the levels of ferritin and B12 used to classify patients as iron-deficient or Vitamin B12–deficient, respectively. Their questions raise the more general issue that there is no universally accepted cut-off level by which either anemia can be diagnosed using a single test. We concede that we might have misclassified a few participants in either direction for each type of anemia.

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