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Comment & Response
September 2017

Intensive Blood Pressure Control on Gait Speed and Mobility Limitation for Older Adults—Reply

Author Affiliations
  • 1School of Biological and Population Health Sciences, Oregon State University, Corvallis
  • 2Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina
  • 3Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina
JAMA Intern Med. 2017;177(9):1396. doi:10.1001/jamainternmed.2017.3004

In Reply We welcome this opportunity to make some clarifications, and to direct readers to previous publications that address many of the concerns raised by Zhang et al.

There has been substantial interest from the scientific community in a complete picture of the net balance of benefits and harms of intensive blood pressure control.1 Because physical function represents one component of this evaluation, our study2 examined changes in gait speed in the subgroup of SPRINT participants 75 years or older at baseline.3 While procedures for the measurement of gait speed were specified in the SPRINT protocol, the authors are correct that gait speed and mobility limitation were not prespecified as outcomes in the protocol or on clinicaltrials.gov. However, gait speed is well-established, well-accepted measure of physical function, and so we reject any allusion that there was selective reporting of the outcomes in our study.2