Every day, nearly 100 people die violently on roadways in the United States, and more than 6500 are injured.1 Motor vehicle crashes are the leading cause of death for Americans aged between 16 and 24 years and the second leading cause for children aged 4 to 15 years.2 Following a decade of declines, the number of US crash deaths abruptly increased by 7.2% in 2015 compared with 2014; early estimates for 2016 point to a further 8% increase (Figure).1,3 In response to this alarming reversal, a coalition of safety, industry, technology, and roadway infrastructure organizations has mobilized to address this immediate crisis and to develop a vision and plan for eliminating road fatalities within 30 years. The health community can play a key role in influencing policies and behaviors to achieve this goal.