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Comment & Response
November 2017

Thyroid Dysfunction in Torsades de Pointes—Reply

Author Affiliations
  • 1Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
JAMA Intern Med. 2017;177(11):1693-1694. doi:10.1001/jamainternmed.2017.4903

In Reply We would like to thank Dr Rizvi for the insightful comments on our case report.1 Dr Rizvi has eloquently detailed the association of hypothyroidism with QT prolongation and subsequent torsades de pointes (TdP). In our case, hypothyroidism did not play a role in the mechanism of TdP because the patient’s thyroid function tests were within normal limits. However, the mechanisms underlying hypothyroidism and amiodarone-induced QT prolongation cover important concepts that can be applied more broadly.