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Comment & Response
January 2018

Limitations of Observational Data in Interpreting SPRINT Results—Reply

Author Affiliations
  • 1Division of Renal Diseases and Hypertension, the Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, Ireland
JAMA Intern Med. 2018;178(1):155. doi:10.1001/jamainternmed.2017.7221

In Reply We agree that our study does not prove that applying the SPRINT protocol to those patients 75 years and older will lead to harm. However, we believe our study1 questions the external validity of the injurious falls and syncope rate seen in SPRINT, because the baseline rate in the target population appears to be considerably higher than the standard care arm of the trial.2 This fact emphasizes the need for physicians to individualize the application of intensive hypertension treatment for elders.

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