The recent recommendations from the American College of Cardiology and the American Heart Association (ACC/AHA) to lower the thresholds for defining hypertension and for treating higher-risk patients1 have been controversial. For example, the Clinical Guidelines Committee of the American College of Physicians (ACP) argued that the changes are “not supported by evidence and may result in low-value care,”2 and the American Academy for Family Physicians (AAFP) raised concerns that the “harms of treating a patient to a lower blood pressure (BP) were not assessed.”3 The Table summarizes key differences between the ACC/AHA guideline and prior guidelines.6,7