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Editor's Note
Less Is More
September 2018

Statin-Associated Myopathy—An Elusive Clinical Problem

Author Affiliations
  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
  • 2Health Care Policy and Law Editor, JAMA Internal Medicine
JAMA Intern Med. 2018;178(9):1230. doi:10.1001/jamainternmed.2018.3128

Muscle disorders resulting from statin therapy, the most common manifestation of statin intolerance, are vexing to both patients and physicians. Statin-associated myopathy may appear as a spectrum of manifestations that include myalgias, myopathy, myositis, myonecrosis, and rhabdomyolysis.1

Myonecrosis and rhabdomyolysis are uncommon, occurring in fewer than 1% of statin-treated patients, but myalgias and myopathy without creatine kinase elevation are reported in up to 5% of patients in clinical trials and in 25% or more in observational studies and clinical experience. To aid in the diagnosis of this often enigmatic condition, the American College of Cardiology provides a statin intolerance mobile app (http://www.acc.org/statinintoleranceapp).

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