To the Editor We read with great interest the recent report by Mitchell and colleagues regarding the efficacy of topical low-dose vaginal estrogen vs topical vaginal moisturizer or placebo for treating postmenopausal vulvovaginal symptoms.1(p681) We are concerned with the authors’ conclusion that “…neither prescribed vaginal estradiol tablet nor over-the-counter vaginal moisturizer provides additional benefit over placebo vaginal tablet and gel in reducing postmenopausal vulvovaginal symptoms.”1
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Reichman O, Sobel JD. Good Clinical Practice in Diagnosis of Vulvovaginal Symptoms. JAMA Intern Med. 2018;178(8):1135–1136. doi:10.1001/jamainternmed.2018.2872
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