Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, but it does not have to be. Screening prevents CRC by finding precancerous lesions so they can be removed before they become cancerous. Screening can also detect CRC early and, when CRC is localized, 5-year survival is over 90%, with many patients cured. Five-year survival for late-stage CRC, however, is less than 20%.1