To the Editor Loftfield and colleagues1 reported on the association between coffee consumption and mortality, and used genetic variants affecting caffeine metabolism to determine the contribution of caffeine to any associations observed. They concluded that coffee consumption is inversely associated with overall mortality regardless of genetic differences affecting caffeine metabolism.
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García-Bailo B, Guest N, El-Sohemy A. The Alleged Health-Protective Effects of Coffee. JAMA Intern Med. 2018;178(12):1724–1725. doi:10.1001/jamainternmed.2018.5807
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