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Comment & Response
December 2018

The Alleged Health-Protective Effects of Coffee

Author Affiliations
  • 1Division of Life Sciences and Medicine, First Affiliated Hospital of the University of Science and Technology of China, Hefei, Anhui, China
  • 2Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
JAMA Intern Med. 2018;178(12):1725-1726. doi:10.1001/jamainternmed.2018.6071

To the Editor We read with interest the study by Loftfield and colleagues1 in which they found an inverse association between coffee consumption and mortality, regardless of genetic caffeine metabolism score.

We noticed that conventional Cox models were used to estimate the hazard ratios (95% CIs) of both all-cause and cause-specific mortality between groups.1 However, we wonder if this indiscriminate use might not have performed well in the hazard ratio estimation of the latter, because the true absolute risks of cause-specific mortality were overestimated owing to the presence of competing risks. A similar issue has been highlighted in previous literature.2,3

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