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December 10, 2018

Precision Medicine and Advancing Clinical Care: Insights From Iceland

Author Affiliations
  • 1Division of Cardiology, Internal Medicine Services, Landspitali–The National University Hospital of Iceland, Reykjavik
  • 2Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik
  • 3Division of Nephrology, Internal Medicine Services, Landspitali–The National University Hospital of Iceland, Reykjavik
JAMA Intern Med. Published online December 10, 2018. doi:10.1001/jamainternmed.2018.6729

Despite an emphasis on clinical practice guidelines based on evidence from randomized clinical trials, medicine in many ways remains an inexact science. The limits of evidence-based medicine are apparent, including knowledge gaps from lack of high-quality clinical data.1 Moreover, the “one size fits all” strategy, designed for the average patient, is hampered by the biological variability that leads to heterogeneity in disease expression.

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