In Reply We agree that our findings1 provide key evidence that air filters merit further study as an adjuvant approach to help manage hypertension. However, it is a misinterpretation of the data to state that air filters only lowered blood pressure (BP) among obese patients. The a priori primary end point was significantly met in the full study cohort (Figure 2A). The subgroup results (Figure 2C) were secondary analyses that only provided hypothesis-generating evidence for effect modification by obesity. This differential response can now be directly tested in follow-up studies.
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Brook RD, Morishita M. Limitations in the Methodology Assessing Blood Pressure and the Need for Strict Exclusion Criteria—Reply. JAMA Intern Med. 2019;179(2):275–276. doi:10.1001/jamainternmed.2018.7483
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