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Comment & Response
February 2019

Limitations in the Methodology Assessing Blood Pressure and the Need for Strict Exclusion Criteria—Reply

Author Affiliations
  • 1Division of Cardiovascular Medicine, University of Michigan, Ann Arbor
  • 2Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing
JAMA Intern Med. 2019;179(2):275-276. doi:10.1001/jamainternmed.2018.7483

In Reply We agree that our findings1 provide key evidence that air filters merit further study as an adjuvant approach to help manage hypertension. However, it is a misinterpretation of the data to state that air filters only lowered blood pressure (BP) among obese patients. The a priori primary end point was significantly met in the full study cohort (Figure 2A). The subgroup results (Figure 2C) were secondary analyses that only provided hypothesis-generating evidence for effect modification by obesity. This differential response can now be directly tested in follow-up studies.

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