[Skip to Content]
[Skip to Content Landing]
Views 83
Citations 0
Comment & Response
February 2019

Limitations in the Methodology Assessing Blood Pressure and the Need for Strict Exclusion Criteria—Reply

Author Affiliations
  • 1Division of Cardiovascular Medicine, University of Michigan, Ann Arbor
  • 2Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing
JAMA Intern Med. 2019;179(2):275-276. doi:10.1001/jamainternmed.2018.7483

In Reply We agree that our findings1 provide key evidence that air filters merit further study as an adjuvant approach to help manage hypertension. However, it is a misinterpretation of the data to state that air filters only lowered blood pressure (BP) among obese patients. The a priori primary end point was significantly met in the full study cohort (Figure 2A). The subgroup results (Figure 2C) were secondary analyses that only provided hypothesis-generating evidence for effect modification by obesity. This differential response can now be directly tested in follow-up studies.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words