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Research Letter
February 18, 2019

Assessment of Price Changes of Existing Tumor Necrosis Factor Inhibitors After the Market Entry of Competitors

Author Affiliations
  • 1Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 2Insurance Services Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
JAMA Intern Med. 2019;179(5):713-716. doi:10.1001/jamainternmed.2018.7656

Before 2009, etanercept, infliximab, and adalimumab were the only tumor necrosis factor (TNF) inhibitors approved by the US Food and Drug Administration for rheumatoid arthritis. Subsequently, 3 therapies have gained US Food and Drug Administration approval: subcutaneous golimumab (April 2009),1 certolizumab pegol (May 2009),2 and intravenous golimumab (July 2013).3 All 6 agents are brand-name drugs. We assessed how the prices of existing TNF inhibitors changed in response to the market entry of new TNF inhibitors.

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