One in 7 Americans (approximately 30 million individuals) has chronic kidney disease (CKD). Beyond heightened risk of end-stage renal disease, these individuals are at high risk of cardiovascular disease, frailty, cognitive impairment, and premature death. Chronic kidney disease is widely recognized as a major public health concern in both the United States and worldwide. Diabetes is the most common cause of CKD, and most epidemiology texts list hypertension as the second most common cause. However, some experts believe that hypertension may in fact be the consequence rather than the cause of this large fraction of CKD,1 and in the absence of biopsy data in most patients, the actual cause remains unclear. Identifying novel risk factors for the development and progression of CKD is important, particularly if such factors are common in the population and modifiable.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Ix JH. Implications of Oxalate as a Novel Risk Factor for Chronic Kidney Disease. JAMA Intern Med. 2019;179(4):551–552. doi:10.1001/jamainternmed.2018.7987
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: