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Comment & Response
March 2019

A Case for n-of-1 Trials

Author Affiliations
  • 1Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
JAMA Intern Med. 2019;179(3):452. doi:10.1001/jamainternmed.2018.7166

To the Editor In a recent issue of JAMA Internal Medicine, Kravitz and colleagues1 presented a randomized clinical trial comparing n-of-1 trials with usual care. Use of n-of-1 trials is highly relevant to recent emerging themes in health research, such as patient-centered research as well as personalized and precision medicine. Use of n-of-1 trials has been shown as useful across a broad range of health conditions and a diverse array of health interventions.2 The Oxford Centre for Evidence-Based Medicine considers n-of-1 trials level 1A evidence.3

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