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Comment & Response
March 2019

Low-Dose Amitriptyline for Chronic Low Back Pain

Author Affiliations
  • 1Institute for Musculoskeletal Health, Sydney School of Public Health, Faculty of Health and Medicine, The University of Sydney, Sydney, Australia
  • 2Sydney Pharmacy School, Faculty of Health and Medicine, The University of Sydney, Sydney, Australia
JAMA Intern Med. 2019;179(3):450. doi:10.1001/jamainternmed.2018.8140

To the Editor We thank Dr Urquhart and colleagues for their recent trial of low-dose amitriptyline in people with chronic low back pain.1 However, the interpretation of their findings—that amitriptyline may be an effective treatment for chronic low back pain and a possible strategy to avoid using opioid analgesics—is problematic as it is not supported by the data presented.

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