[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.173.234.169. Please contact the publisher to request reinstatement.
Views 160
Citations 0
Comment & Response
March 2019

Inconsistencies in Reporting Studies of Lactic Acidosis

Author Affiliations
  • 1Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
JAMA Intern Med. 2019;179(3):455-456. doi:10.1001/jamainternmed.2018.8627

To the Editor In their recently published Original Investigation regarding metformin use, renal function, and acidosis, Lazarus and colleagues1 explained why their findings were different than ours2 and wrote that our study “was limited by sparse [estimated glomerular filtration rate] data and did not account for changes in [estimated glomerular filtration rate] over time.”1(909) This is not true. Table 2 in our article2 summarized that we were able to classify more than 90% of metformin exposure time to renal function. In addition, our methods section clearly stated that we determined renal function during follow-up time and ran our analysis using a time-varying Cox regression analysis in which we modeled both changes in metformin exposure and changes in renal function over calendar time.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×